PARP inhibitor combination therapy
Cet article passe en revue les études pré-cliniques et cliniques concernant l'intérêt des traitements anticancéreux combinant inhibiteurs de PARP et autres agents thérapeutiques (témozolomide, gemcitabine, inhibiteurs PI3K/mTOR, ...), puis analyse les perspectives futures de ces stratégies thérapeutiques ainsi que les défis associés à leur développement
In 2014, olaparib (Lynparza) became the first PARP (Poly(ADP-ribose) polymerase) inhibitor to be approved for the treatment of cancer. When used as single agents, PARP inhibitors can selectively target tumour cells with BRCA1 or BRCA2 tumour suppressor gene mutations through synthetic lethality. However, PARP inhibition also shows considerable promise when used together with other therapeutic agents. Here, we summarise both the pre-clinical and clinical evidence for the utility of such combinations and discuss the future prospects and challenges for PARP inhibitor combinatorial therapies.
Critical Reviews in Oncology / Hematology , résumé, 2015