Basket Trials in Oncology: A Trade-Off Between Complexity and Efficiency
Cet article analyse les enjeux associés à l'évaluation de thérapies ciblées dans le cadre d'essais de type "panier", pour lesquels seule la présence d'une cible moléculaire est requise, indépendamment de la localisation de la tumeur
The current oncology drug development landscape is dominated by efforts to create therapies that are mechanistically designed to improve outcomes for patients with cancers that harbor specific molecular aberrations, which often occur across a variety of tumor types. In the evaluation of targeted therapies, basket trials have emerged as an approach to test the hypothesis that targeted therapies may be effective independent of tumor histology, as long as the molecular target is present. However, the term basket has been applied broadly, and there is little uniformity in the design or goals of these trials...
Journal of Clinical Oncology , article en libre accès, 2015