The disparate origins of ovarian cancers: pathogenesis and prevention strategies
Cet article passe en revue les travaux récents suggérant que les carcinomes séreux ovariens de haut grade, les carcinomes à cellules claires et les carcinomes endométrioïdes se développent à partir de tissus qui, normalement, ne sont pas présents dans un ovaire
Ovarian cancer is the fifth cause of cancer-related death in women and comprises a histologically and genetically broad range of tumours, including those of epithelial, sex cord-stromal and germ cell origin. Recent evidence indicates that high-grade serous ovarian carcinoma, clear cell carcinoma and endometrioid carcinoma primarily arise from tissues that are not normally present in the ovary. These histogenetic pathways are informing risk-reduction strategies for the prevention of ovarian and ovary-associated cancers and have highlighted the importance of the seemingly unique ovarian microenvironment.