Home Remodeling and Risk of Childhood Leukemia
Menée aux Etats-Unis et portant sur 609 patients atteints d'une leucémie lymphoblastique aiguë, 89 patients atteints d'une leucémie myéloïde aiguë et sur 893 témoins, cette étude évalue l'association entre une activité de bricolage générant une exposition domestique à des produits chimiques et le risque de développer la maladie chez l'enfant
Purpose : We investigated the relationship between the risk of childhood leukemia and home remodeling, a surrogate for indoor chemical exposures. Methods : We collected information on remodeling activities carried out between birth and diagnosis in homes of 609 acute lymphoblastic leukemia (ALL) cases, 89 acute myeloid leukemia (AML) cases, and 893 matched controls participating in the California Childhood Leukemia Study (1995 – 2008). We used multivariable logistic regression to estimate the risk of ALL and AML associated with six remodeling activities: construction, painting, recarpeting, reflooring, roofing, and weather proofing. Models were adjusted for age, sex, Hispanic ethnicity, race, household annual income, and residential mobility. Results : Construction in the home between birth and diagnosis was associated with a significant increase in ALL risk (OR: 1.52, 95% CI: 1.14, 2.02) and a non-significant increase in AML risk (OR: 1.75, 95% CI: 0.98, 3.15). No other remodeling activities were associated with ALL or AML risk in the main analysis. When stratifying by Hispanic ethnicity, a positive relationship between ALL risk and painting was evident in Hispanic children (OR: 1.47, 95% CI: 1.04, 2.07). Conclusions : Specific home remodeling activities appeared to be associated with increased risk of childhood ALL.