Gestational diabetes mellitus may be associated with increased risk of breast cancer
A partir de données portant sur 50 884 participantes âgées de 35 à 74 ans, cette étude de cohorte évalue l'association entre un diabète gestationnel et le risque de cancer du sein
Background: Although a positive association between type 2 diabetes and breast cancer has been reported, an association with gestational diabetes mellitus (GDM) is less clear. Methods: The Sister Study enroled 50 884 women aged 35–74 years, from 2003 through 2009. Cox proportional hazards models were used to estimate breast cancer risk in relation to GDM. Results: Ever having GDM was not associated with breast cancer overall (hazards ratio (HR)=1.10, 95% confidence interval (CI)=0.88–1.36), but there was a suggestive association between ever having a GDM pregnancy and oestrogen receptor (ER) -negative breast cancer (HR=1.73, 95% CI=0.98–3.06). However, having 2 or more GDM pregnancies was associated with overall breast cancer risk 1.68 (95% CI=1.15–2.44) and with ER-positive breast cancer (HR=1.81, 95% CI=1.10–2.98), which was supported by sensitivity analyses. Results were similar when analyses were stratified by whether or not type 2 diabetes had developed after GDM. Conclusions: Women with multiple GDM pregnancies had a higher incidence of breast cancer, suggesting that such women could benefit from increased surveillance for breast cancer.