Anal cancer: from an orphan disease to a curable malignancy?
Mené sur 37 patients atteints d'un carcinome épidermoïde du canal anal non résécable et métastatique, cet essai de phase II évalue l'efficacité, du point de vue du taux de réponse, et la toxicité du nivolumab en monothérapie
Squamous cell carcinoma of the canal anal (SCCA) is rare, accounting for roughly 2% of all gastrointestinal cancers.1 It is mainly caused by infection with human papillomavirus followed by immune deficiency such as that induced by immunosoppressive treatments after organ transplantation or HIV infection.2
The Lancet Oncology , commentaire, 2016