Physical activity and lung cancer risk in men and women
Mené auprès de 727 patients atteints d'un cancer du poumon et auprès de 1 351 témoins, cette étude évalue, en fonction du sexe, l'association entre le niveau d'activité physique (de loisir ou liée à l'activité professionnelle) et le risque de développer la maladie
Purpose : Although evidence has accumulated that recreational physical activities (PA) may reduce lung cancer risk, there is little evidence concerning the possible role of a potentially more important source of PA, namely occupational PA. We investigated both recreational and lifetime occupational PA in relation to lung cancer risk in a population-based case–control study in Montreal, Canada (NCASES = 727; NCONTROLS = 1,351). Methods : Unconditional logistic regression was used to estimate odds ratios (OR), separately for men and women, adjusting for smoking, exposure to occupational carcinogens, and sociodemographic and lifestyle factors. Results : In both sexes, increasing recreational PA was associated with a lower lung cancer risk (ORMEN = 0.66, 95% confidence interval (CI) 0.47–0.92; ORWOMEN = 0.55, 95% CI 0.34–0.88, comparing the highest versus lowest tertiles). For occupational PA, no association was observed among women, while increasing occupational PA was associated with increased risk among men (ORMEN = 1.96, 95% CI 1.27–3.01). ORs were not modified by occupational lung carcinogen exposure, body mass index, and smoking level; results were similar across lung cancer histological types. Conclusions : Our results support the previous findings for recreational PA and lung cancer risk. Unexpectedly, our findings suggest a positive association for occupational PA; this requires replication and more detailed investigation.