Multicenter prospective evaluation of the reliability of the combined use of two models to predict non-sentinel lymph node status in breast cancer patients with metastatic sentinel lymph nodes : the MSKCC nomogram and the Tenon score. Results of the NOTEGS study
Menée à partir de données portant sur 2 822 patientes atteintes d'un cancer du sein, cette étude multicentrique évalue l'intérêt d'utiliser conjointement le nomogramme "MSKCC" (Memorial Sloan Kettering Cancer Center) et le système de score "Tenon" pour identifier, parmi les patientes dont le ganglion sentinelle est positif, celles présentant un faible risque de métastases et pouvant éviter un curage ganglionnaire axillaire
Background : The purpose of this study was to prospectively evaluate the combined use of The Memorial Sloan Kettering Cancer Center nomogram and Tenon score to select, in patients with metastatic sentinel lymph node (SN), those at low risk of metastatic non-SN for whom additional axillary lymph node dissection (ALND) could be avoided.
Methods : From January 2011 to July 2012, a prospective non-interventional nationwide study was conducted (NCT01509963). We sought to identify the false reassurance rate (FRR, a negative test result is false) in patients with both a less than or equal to10% probability of metastatic non-SN with the MSKCC nomogram and a Tenon score less than or equal to3.5 (low risk): the proportion of patients with metastatic non-SN at additional ALND. Our hypothesis was that these patients would have a FRRless than or equal to5%.
Results : Data on 2822 patients with breast cancer from 53 institutions were prospectively recorded. At least one SN was metastatic (isolated tumour cells, micro- or macrometastases) in 696 patients (24.7%). Among patients with ALND and complete data to calculate combined risk (n=504), 67 and 437 patients had low and high combined risk, respectively. Patients at low risk had less ALND (47%) compared to patients at high risk (P<0.001). This study did not meet its primary objective because the FRR in patients with low risk was 16.4% (11 out of 67) (95% confidence interval (CI): 9.7–23.1%). In the high-risk group, 33.9% (148 out of 437) (95% CI: 29.6–38.4%) had non-SN metastases (P=0.004).
Conclusions : In this controlled prospective study, metastatic SN patients with both a less than or equal to10% probability of metastatic non-SN with the MSKCC nomogram and a Tenon score less than or equal to3.5 failed to identify patients at low risk of metastatic non-SN when completion ALND was not systematic.
British Journal of Cancer , résumé, 2016