Prognostic and predictive ability of tumor sidedness: Another vexing difference between localized and advanced colon cancer
Menée à partir de données portant sur 6 365 patients atteints d'un cancer du côlon de stade précoce traité par résection entre 2002 et 2008 (âge médian : 72 ans), cette étude évalue l'association entre la latéralité de la tumeur et la survie spécifique ou la survie globale
There has been a flurry of recent interest in the effect of primary tumor sidedness on prognosis and treatment response among patients with colorectal cancer (CRC). This interest has largely been sparked by recent observations that among patients with metastatic CRC (mCRC), primary tumor sidedness was associated not only with prognosis but also, among those patients without KRAS mutations, with response to epidermal growth factor receptor (EGFR).1,2 Based on these findings, a number of investigators now advocate for the inclusion of tumor sidedness as an important stratification criteria in the design of future clinical trials. Naturally, these observations have led many investigators to question if tumor sidedness is also prognostic in patients with localized disease.
JAMA Oncology , éditorial en libre accès, 2016