Cardiorespiratory Fitness and Cancer Incidence in Men
Menée aux Etats-Unis auprès de 4 920 participants, cette étude évalue l'association entre la santé cardiorespiratoire et le risque de cancer
Purpose : The preventive role of cardiorespiratory fitness (CRF) in cancer is not well-established. The current study sought to evaluate the association between CRF and cancer incidence in men. Methods : Maximal exercise testing was performed in 4,920 men (59.2±11.4 years) free from malignancy at baseline who were followed for 12.7±7.5 years. Relative risks and population attributable risks (PAR) were determined. Results : During the follow-up, 25.8% were diagnosed with any type of cancer. CRF was inversely associated with total cancer incidence; for each 1 metabolic equivalent increase in CRF there was a 4% reduction in cancer incidence (p<0.001). Compared to low CRF, moderate and high CRF levels were associated with 14% [95% CI (0.74-0.99)] and 26% [95% CI (0.62-0.89)] reduced risks for all cancers, respectively (p for trend =0.004). Low CRF had a PAR of 3.0% for cancer incidence. The associations between CRF, prostate, skin and colorectal cancers were not significant. Conclusions : Higher CRF is associated with lower total cancer incidence in men. A novel finding suggests that eliminating low CRF as a risk factor would potentially prevent considerable cancer morbidity and reduce the societal and economic burden associated with cancer. These findings underscore the importance of CRF for primary cancer prevention.