Trichomonas vaginalis infection and risk of prostate cancer: associations by disease aggressiveness and race/ethnicity in the PLCO Trial
A partir de données portant sur 925 patients de type caucasien atteints d'un cancer de la prostate, sur 201 patients afro-américains atteints d'un cancer de la prostate et sur 1 216 témoins, cette étude évalue l'association entre une infection par le trichomonas vaginalis et le risque de développer la maladie, en fonction du stade de la maladie et de l'origine ethnique
Purpose : Results from previous sero-epidemiologic studies of Trichomonas vaginalis infection and prostate cancer (PCa) support a positive association between this sexually transmitted infection and aggressive PCa. However, findings from previous studies are not entirely consistent, and only one has investigated the possible relation between T. vaginalis seropositivity and PCa in African-American men who are at highest risk of both infection and PCa. Therefore, we examined this possible relation in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, including separate analyses for aggressive PCa and African-American men. Methods : We included a sample of participants from a previous nested case–control study of PCa, as well as all additional Caucasian, aggressive, and African-American cases diagnosed since the previous study (total n = 438 Gleason 7 Caucasian cases, 487 more advanced Caucasian cases (≥Gleason 8 or stage III/IV), 201 African-American cases, and 1216 controls). We tested baseline sera for T. vaginalis antibodies. Results : No associations were observed for risk of Gleason 7 (odds ratio (OR) = 0.87, 95% confidence interval (CI) 0.55–1.37) or more advanced (OR = 0.90, 95% CI 0.58–1.38) PCa in Caucasian men, or for risk of any PCa (OR = 1.06, 95% CI 0.67–1.68) in African-American men. Conclusions : Our findings do not support an association between T. vaginalis infection and PCa.