Surveillance in germline TP53 mutation carriers utilizing whole-body magnetic resonance imaging
Ce dossier présente un ensemble d'articles sur les stratégies de surveillance et le dépistage des cancers chez les personnes présentant une prédisposition génétique (syndrome de Lynch ou syndrome de Li-Fraumeni)
Germline TP53 mutations are associated with Li-Fraumeni syndrome (LFS).1 Mutation carriers ascertained on family history have an extremely high lifetime risk of multiorgan cancers.2 Unlike hereditary breast or bowel cancer syndromes, there are no consensus guidelines for screening in LFS, although emerging data suggest a benefit from surveillance.3 Herein, we report preliminary data from a prospective study of a whole-body screening program that includes whole-body magnetic resonance imaging (WBMRI) in carriers of germline mutations in TP53.
JAMA Oncology , résumé, 2016