Recent trends in ovarian cancer incidence and relative survival in the U.S. by race/ethnicity and histologic subtypes
A partir de données des registres américains des cancers sur la période 2000-2013, cette étude analyse les disparités ethniques dans l'évolution de l'incidence du cancer de l'ovaire et dans la survie relative, en fonction du sous-type histologique de la maladie
Background: Incidence and survival rates of non-serous epithelial ovarian cancer in racial/ethnic minorities remain relatively unknown in the United States (U.S.). We examine the trends in incidence and survival rates for epithelial ovarian cancer by histologic subtypes and race/ethnicity. Methods: Ovarian cancer incidence and mortality data from 2000-2013 were obtained from Surveillance, Epidemiology, and End Results database. Age-adjusted incidence rate, incidence rate ratio, and annual percentage changes (APC) were calculated by histology and race/ethnicity subgroups and stratified by age at diagnosis. Five-year relative survival rates were calculated by stage and race/ethnicity. Results: A small but significant decrease in incidence rates were seen in non-Hispanic white (NHW), non-Hispanic black (NHB), and Hispanic women (APC -1.58, -0.84, -1.31, respectively) while incidence rates remained relatively stable in Asian women (APC -0.37). With exception of significant increase in incidence rate of clear cell carcinoma among Asian woman (APC 1.85), an overall trend towards decreasing incidence rates were seen across histologic subtypes and age-strata, although not all results were statistically significant. Compared to NHW women, NHB women experienced poorer five-year survival at every stage across histologic subtypes while Hispanic and Asian women had equivalent or better survival. Conclusions: Over the last decade, incidence rates of epithelial ovarian cancer in the U.S. have decreased or remained stable across race/ethnic and histologic subgroups, except for clear cell carcinoma. Survival remains poorest among NHB women. Impact: Comparative histologic subtype distribution and incidence trends do not explain the ovarian cancer survival disparity disproportionately affecting NHB women.