Serum 25-hydroxyvitamin D concentrations and lung cancer risk in never-smoking postmenopausal women
Menée auprès de 298 femmes ménopausées n'ayant jamais fumé mais atteintes d'un cancer du poumon et menée auprès de 298 témoins, cette étude évalue, en fonction de la concentration sérique en vitamine A et de la consommation de vitamine D en supplémentation, l'association entre le niveau sérique de 25-hydroxyvitamine D et le risque de cancer du poumon par sous-type (adénocarcinome, cancer du poumon non à petites cellules)
Purpose : Vitamin D has been implicated in lowering lung cancer risk, but serological data on the association among never-smoking women are limited. We report results examining the association of serum 25-hydroxyvitamin D [25(OH)D] concentrations with lung cancer risk among female never smokers. We also examined whether the association was modified by vitamin D supplementation and serum vitamin A concentrations. Methods : In the Women’s Health Initiative, including the calcium/vitamin D (CaD) Trial, we selected 298 incident cases [191 non-small cell lung cancer (NSCLC) including 170 adenocarcinoma] and 298 matched controls of never smokers. Baseline serum 25(OH)D was assayed by a chemiluminescent method. Logistic regression was used to estimate odds ratios (ORs) for quartiles and predefined clinical cutoffs of serum 25(OH)D concentrations. Results : Comparing quartiles 4 versus 1 of serum 25(OH)D concentrations, ORs were 1.06 [95% confidence interval (CI) 0.61–1.84] for all lung cancer, 0.94 (95% CI 0.52–1.69) for NSCLC, and 0.91 (95% CI 0.49–1.68) for adenocarcinoma. Comparing serum 25(OH)D ≥ 75 (high) versus <30 nmol/L (deficient), ORs were 0.76 (95% CI 0.31–1.84) for all lung cancer, 0.71 (95% CI 0.27–1.86) for NSCLC, and 0.81 (95% CI 0.31–2.14) for adenocarcinoma. There is suggestive evidence that CaD supplementation (1 g calcium + 400 IU D3/day) and a high level of circulating vitamin A may modify the associations of 25(OH)D with lung cancer overall and subtypes (p interaction <0.10). Conclusions : In this group of never-smoking postmenopausal women, the results did not support the hypothesis of an association between serum 25(OH)D and lung cancer risk.