Sorafenib and continued erlotinib or sorafenib alone in patients with advanced non-small cell lung cancer progressing on erlotinib: A randomized phase II study of the Sarah Cannon Research Institute SCRI
Mené sur 52 patients atteints d'un cancer du poumon non à petites cellules de stade métastatique ayant progressé après un premier traitement par erlotinib, cet essai de phase II évalue l'efficacité, du point de vue de la survie sans progression, et la toxicité de l'ajout de l'erlotinib au sorafénib en traitement de seconde ligne
Purpose : To evaluate the efficacy of erlotinib, continued after tumor progression, plus sorafenib versus sorafenib alone in patients with refractory metastatic non-small cell lung cancer (NSCLC) who previously benefitted from single-agent erlotinib. Patients and Methods : Patients with progressive refractory NSCLC who had previously benefitted from erlotinib (objective response or stable disease > 8 weeks) were randomized to receive treatment with either sorafenib (400 mg orally twice daily) or sorafenib alone. Patients were evaluated for response every 8 weeks, and continued treatment until disease progression or intolerable toxicity. Results : Fifty-three patients were randomized (erlotinib/sorafenib, 25; sorafenib, 28) and 52 patients received study treatment. Patients in both groups received a median of 8 weeks of treatment. The median PFS was 3.1 months for erlotinib/sorafenib versus 1.7 months for sorafenib alone; response rates were 8% and 4%, respectively. Both regimens were tolerable, but toxicity was more frequent with erlotinib/sorafenib. Conclusions : These results do not suggest any benefit in continuing erlotinib after tumor progression in patients with refractory metastatic NSCLC. Both regimens tested had limited efficacy, consistent with results from other studies.