Maternal diabetes and risk of childhood acute lymphoblastic leukaemia in the offspring
Menée au Danemark à partir de données portant sur 1 187 482 enfants nés entre 1996 et 2015, cette étude évalue l'association entre un diabète maternel, gestationnel ou antérieur à la grossesse, et le risque de leucémie lymphoblastique aiguë pendant l'enfance
Background: Maternal diabetes may be linked to childhood acute lymphoblastic leukaemia (ALL) in the offspring. Methods: We assessed the association between maternal pregestational or gestational diabetes and offspring risk of childhood ALL in a register-based study, including all singletons born in Denmark during 1996–2015 (n=1 187 482). Results: Adjusted hazard ratios of childhood ALL were 2.91 (95% confidence interval (CI): 1.30–6.51) for maternal pregestational diabetes and 1.75 (95% CI: 1.02–2.98) for maternal gestational diabetes. Paternal diabetes did not alter offspring ALL risk, and we found no association between offspring ALL and later maternal risk of diabetes. Conclusions: Regardless that absolute ALL risk among offspring of women with diabetes remains low, our findings suggest that characteristics of the diabetic intrauterine environment promote ALL development. This offers a setting for future research into the biological mechanisms underlying childhood ALL.