Emerging treatment paradigms in brain metastasis in non-small cell lung cancer : an overview of the current landscape and challenges ahead
Cet article passe en revue les stratégies thérapeutiques pour traiter des métastases cérébrales chez les patients atteints d'un cancer du poumon non à petites cellules, puis analyse les progrès à réaliser pour améliorer et optimiser les traitements
Advances in the last decade in genomic profiling and the identification of druggable targets amenable to biological agents, has transformed the management and survival of a subgroup of patients with brain metastasis in non-small cell lung cancer. In parallel, clinicians have re-evaluated the role of whole brain radiotherapy in selected patients with brain metastases to reduce neurocognitive toxicity. Continual progress in this understudied field is required: optimisation of the sequence of schedules for therapies in patients with brain metastases of differing genomic profiles, focusing on new strategies to overcome mechanisms of biological resistance and increasing drug penetrability into the central nervous system. This review summarises the field to date and possible treatment strategies based on current evidence.
Annals of Oncology , résumé, 2016