Characterizing an ultra–high-risk subset of patients with hypopharynx and larynx cancer: The power of lymph node burden
Menée à partir de données portant sur 8 351 patients atteints d'un carcinome épidermoïde du larynx ou de l'hypopharynx traité par résection entre 2004 et 2013 (âge moyen : 61 ans), cette étude évalue l'association entre le nombre de ganglions lymphatiques atteints et la survie globale des patients
Staging systems for squamous cell carcinoma of the head and neck (SCCHN) vary by anatomic subsite. Nodal classifications across subsites are similar and are based on the size, number, and laterality of positive regional lymph nodes (LNs). In clinical practice, it is commonly held that contralateral nodal metastases are a poor prognosticator, and the same logic is generally applied to cases with large positive nodes. The American Joint Committee on Cancer’s AJCC Staging Manual, 8th edition, to be implemented in 2018, continues using the traditional nodal characteristics and adds extranodal extension as an important feature.
JAMA Oncology , commentaire, 2016