The importance of HPV16 in anal cancer prevention
A partir d'une revue systématique de la littérature publiée entre 1992 et 2017 (95 études, 18 646 participants), cette méta-analyse évalue la prévalence d'une infection par le papillomavirus humain (HPV) et son association avec le risque d'un cancer de l'anus, en fonction du sexe de l'individu, d'une co-infection par le VIH et du sous-type de HPV
Like cervical cancer, anal cancer and its direct precursor lesion, high-grade anal intraepithelial neoplasia (AIN), are caused by persistent infections with human papillomaviruses (HPV).1 The natural history of HPV in cervical cancer has been comprehensively investigated. In the more than 40 HPV types infecting the anogenital tract, high-risk HPV-types and possible or probable high-risk types for the development of cervical cancer have been defined.2 Cervical cancer is preventable by regular screening. Many countries are currently replacing cytological Pap-screening by primary HPV-screening or HPV and cytology co-testing in women over the age of 30 years.3 By contrast with cervical cancer, anal cancer screening is still a matter of debate, even for high-risk populations such as men who have sex with men and HIV-positive individuals.4, 5 In other unsettled aspects of anal cancer screening, a gap of knowledge exists on the carcinogenicity of different HPV types in the anus.