Human T Cell Development, Localization, and Function throughout Life
Cet article passe en revue les travaux récents sur le développement des lymphocytes T, leur localisation anatomique et leur rôle dans la réponse immunitaire tout au long de la vie, suggérant l'importance de prendre en compte l'influence de l'âge et d'un tissu sur les lymphocytes T pour mettre en oeuvre des stratégies immunothérapeutiques
Throughout life, T cells coordinate multiple aspects of adaptive immunity, including responses to pathogens, allergens, and tumors. In mouse models, the role of T cells is studied in the context of a specific type of pathogen, antigen, or disease condition over a limited time frame, whereas in humans, T cells control multiple insults simultaneously throughout the body and maintain immune homeostasis over decades. In this review, we discuss how human T cells develop and provide essential immune protection at different life stages and highlight tissue localization and subset delineation as key determinants of the T cell functional role in immune responses. We also discuss how anatomic compartments undergo distinct age-associated changes in T cell subset composition and function over a lifetime. It is important to consider age and tissue influences on human T cells when developing targeted strategies to modulate T cell-mediated immunity in vaccines and immunotherapies.
Immunity , résumé, 2017