Influence of obesity-related risk factors in the aetiology of glioma
A partir de données d'une étude d'association sur le génome entier incluant 12 488 patients atteints d'un gliome et 18 169 témoins, cette étude évalue l'association entre des caractéristiques liées à une obésité (indice de masse corporelle, rapport taille-hanches, diabète de type 2, résistance à l'insuline, hyperglycémie) et le risque de développper la maladie, par sous type
Background : Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation framework to examine whether obesity-related traits influence glioma risk. This methodology reduces bias from confounding and is not affected by reverse causation. Methods : Genetic instruments were identified for 10 key obesity-related risk factors, and their association with glioma risk was evaluated using data from a genome-wide association study of 12,488 glioma patients and 18,169 controls. The estimated odds ratio of glioma associated with each of the genetically defined obesity-related traits was used to infer evidence for a causal relationship. Results : No convincing association with glioma risk was seen for genetic instruments for body mass index, waist-to-hip ratio, lipids, type-2 diabetes, hyperglycaemia or insulin resistance. Similarly, we found no evidence to support a relationship between obesity-related traits with subtypes of glioma–glioblastoma (GBM) or non-GBM tumours. Conclusions : This study provides no evidence to implicate obesity-related factors as causes of glioma.