CAR T cell immunotherapy for human cancer
Ce dossier présente un ensemble d'articles concernant différents types d'immunothérapies dans le traitement des cancers (lymphocytes CAR-T, inhibiteurs de point de contrôle immunitaire ou vaccins) ainsi que le rôle du microbiome dans l'efficacité de ces traitements
Adoptive T cell transfer (ACT) is a new area of transfusion medicine involving the infusion of lymphocytes to mediate antitumor, antiviral, or anti-inflammatory effects. The field has rapidly advanced from a promising form of immuno-oncology in preclinical models to the recent commercial approvals of chimeric antigen receptor (CAR) T cells to treat leukemia and lymphoma. This Review describes opportunities and challenges for entering mainstream oncology that presently face the CAR T field, with a focus on the challenges that have emerged over the past several years.
Science , résumé, 2017