The Cancer Immunotherapy Revolution
Ce dossier présente un ensemble d'articles concernant différents types d'immunothérapies dans le traitement des cancers (lymphocytes CAR-T, inhibiteurs de point de contrôle immunitaire ou vaccins) ainsi que le rôle du microbiome dans l'efficacité de ces traitements
Cancer immunotherapy—the science of mobilizing the immune system to kill cancer—has been pursued for more than a century. Yet only recently has this powerful strategy finally taken center stage in mainstream oncology. The past few years have seen unprecedented clinical responses, rapid drug development, and first-in-kind approvals from the U.S. Food and Drug Administration. Reports of terminal cancer patients defying the odds and achieving complete remissions are accumulating. These success stories are the culmination of decades of painstaking research by pioneering scientists and physicians. Newly approved immunotherapies include drugs that can manipulate components of the immune system and methods to genetically engineer patients' own T lymphocytes to recognize and attack their tumors.
Science , commentaire, 2017