NRF2 and the Hallmarks of Cancer
Cet article passe en revue les travaux récents sur les mécanismes par lesquels le facteur de transcription NRF2 exerce des fonctions de suppresseur, ou de promoteur, de tumeurs
The transcription factor NRF2 is the master regulator of the cellular antioxidant response. Though recognized originally as a target of chemopreventive compounds that help prevent cancer and other maladies, accumulating evidence has established the NRF2 pathway as a driver of cancer progression, metastasis, and resistance to therapy. Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establishing NRF2 as a truly pleiotropic transcription factor. In this review, we explore the roles of NRF2 in the hallmarks of cancer, indicating both tumor suppressive and tumor-promoting effects.
Cancer Cell 2018