A Prospective Study of Dietary Polyunsaturated Fatty Acids Intake and Lung Cancer Risk
Menée en Chine à partir des données de deux cohortes incluant 121 970 participants, cette étude prospective évalue l'association entre une consommation d'acides gras poly-insaturés d'origine alimentaire et le risque de cancer du poumon
Animal studies have shown that polyunsaturated fatty acids (PUFAs) have antineoplastic and anti‐inflammatory properties. Results from epidemiologic studies on specific types of PUFAs for lung cancer risk, however, are inconclusive. We prospectively evaluated the association of specific types of dietary PUFA intakes and lung cancer risk in two population‐based cohort studies, the Shanghai Women's Health Study (SWHS) and Shanghai Men's Health Study (SMHS) with a total of 121,970 study participants (i.e., 65,076 women and 56,894 men). Dietary fatty acid intakes were derived from data collected at the baseline using validated food frequency questionnaires (FFQs). Cox proportional hazards model was performed to assess the association between PUFAs and lung cancer risk. Total, saturated and monounsaturated fatty acid intakes were not significantly associated with lung cancer risk. Total PUFAs intake was inversely associated with lung cancer risk [HRs and respective 95% CIs for quintiles 2 to 5 versus quintile 1: 0.84 (0.71‐0.98), 0.97 (0.83‐1.13), 0.86 (0.74‐1.01) and 0.85 (0.73‐1.00), Ptrend=0.11]. However, DHA intake was positively associated with lung cancer risk [HRs and 95% CIs: 1.01 (0.86‐1.19), 1.20 (1.03‐1.41), 1.21 (1.03‐1.42) and 1.24 (1.05‐1.47), Ptrend=0.001]. The ratio of n‐6 PUFAs to n‐3 PUFAs (i.e., 7:1) was inversely associated with lung cancer risk, particularly among never‐smokers and adenocarcinoma patients. Total PUFAs and the ratio between n‐6 PUFAs and n‐3 PUFAs were inversely associated with lung cancer risk. Our current study highlights an important public health impact of PUFA intakes toward intervention/prevention programs of lung cancer. This article is protected by copyright. All rights reserved.