Too Early to Worry About Blueberries
Menée aux Etats-Unis à partir de données portant sur 1 023 patients atteints d'un cancer du côlon de stade III traité par résection, cette étude prospective évalue l'association entre l'indice insulinique de l'alimentation, le risque de récidive et la survie
A dietary factor that has been explored extensively is the glycemic index (an estimate of postprandial glucose levels), which has been associated with colorectal cancer and its progression (2). In this issue of the Journal, Morales-Oyarvide and colleagues focus instead on the related postprandial surge in insulin as a dietary factor affecting survival (3). They report that colorectal cancer patients with the highest dietary insulin load and insulin index have a statistically significantly higher risk for disease-free and overall survival. The associations between insulin scores and survival end points remain statistically significant even after adjusting for body mass index (BMI), physical activity, fiber intake, alcohol intake, tumor characteristics, cancer treatment, and glycemic index and load. Additional subgroup analyses stratified by body mass index show that overweight and obese patients with the highest dietary insulin load have statistically significantly worse disease-free survival, thus underscoring the key role that obesity plays in colorectal cancer. The findings from the present study also corroborate those from this group’s previous investigations, which suggest that the dietary insulin load is statistically significantly associated with colorectal cancer survival (4,5).
Journal of the National Cancer Institute , commentaire, 2017