Statin use and mortality among endometrial cancer patients: a Danish nationwide cohort study
A partir des données du registre danois des cancers portant sur 6 694 patientes âgées de 30 à 84 ans et atteintes d'un cancer de l'endomètre diagnostiqué entre 2000 et 2012, cette étude évalue l'association entre une utilisation de statines et la mortalité spécifique ou la mortalité par autre cause (durée médiane de suivi : 4,5 ans ; 753 décès par cancer de l'endomètre, 765 décès par autre cause)
Statin use has been linked to improved prognosis of some cancer types, however, for endometrial cancer, the results are equivocal. We therefore examined the effect of statin use on endometrial cancer mortality. From the Danish Cancer Registry, we identified all women in Denmark aged 30‐84 years with primary endometrial cancer during 2000‐2012. Data on drug use, mortality outcomes and potential confounders were retrieved from nationwide registries. We used Cox proportional hazards regression models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for endometrial cancer‐specific and other‐cause mortality associated with statin use. Among 6,694 endometrial cancer patients, 753 died from endometrial cancer and 765 from other causes during a median follow‐up of 4.5 year (interquartile range: 1.9‐8.1). We observed an inverse association between time‐varying post‐diagnosis statin use (≥2 prescriptions) and endometrial cancer mortality (HR: 0.61, 95% CI: 0.48‐0.77) compared to non‐use (<2 prescriptions). The associations did not differ substantially by intensity or cumulative amount of statin use. In secondary analyses including pre‐diagnosis statin use, we observed reduced mortality among both continuing (pre‐ and post‐diagnosis) users (HR 0.70, 95% CI 0.53‐0.92) and new (post‐diagnosis only) users (HR 0.43, 95% CI 0.29‐0.65) compared to ‘never users'. In sensitivity analyses with fixed exposure periods following the endometrial cancer diagnosis, the inverse association was more pronounced more than five years after the diagnosis. Our findings suggest that statin use may be associated with improved survival in endometrial cancer patients. This article is protected by copyright. All rights reserved.