Alcohol consumption and risk of gastric cardia adenocarcinoma and gastric non-cardia adenocarcinoma: A 16-year prospective analysis from the NIH-AARP Diet and Health cohort
A partir des données de la cohorte américaine "NIH-AARP Diet and Health" portant sur 490 605 participants d'âge compris entre 50 et 71 ans, cette étude prospective évalue l'association entre une consommation d'alcool et le risque d'adénocarcinome de l'estomac, qu'il s'agisse d'un cancer du cardia ou d'un cancer non-cardia (période de suivi : 16 ans ; 1 375 cas)
The role of alcoholic beverages in the etiology of gastric cancer is unclear. Recent summaries showed a positive association between higher alcohol intake and gastric cancer risk, but the magnitude of association is small, there is moderate heterogeneity among studies, and most cases were from Asian populations. We prospectively investigated the associations of alcohol consumption with gastric cardia adenocarcinoma (GCA) and gastric non-cardia adenocarcinoma (GNCA) in 490,605 adults, aged 50-71 years at baseline who participated in the NIH-AARP Diet and Health Study. Alcohol consumption in the past year was assessed at baseline by questionnaire and defined as total grams of ethanol intake per day or as a categorical variable: non-drinker, up to or including one drink/day, one to three drinks/day, and greater than three drinks/day. We used multivariable-adjusted Cox proportional hazards regression to calculate the hazard ratios (HR) and 95% confidence intervals (CI) for associations between alcohol intake and risk of gastric adenocarcinomas. Through 2011, 662 incident cases of GCA and 713 of GNCA occurred. We found no association between higher alcohol consumption and GCA or GNCA, when examined as total alcoholic beverage intake individual beverage types of beer, wine and liquor. Furthermore, we observed no association by stratum of sex, ethnic group, educational level, or smoking status. We did, however, observe lower risk of GNCA among participants who drank up to one drink per day (HR=0.81, 95%CIs:0.67-0.97) compared to nondrinkers. In conclusion, alcohol consumption was not associated with increased risk of GCA or GNCA in this large US cohort. This article is protected by copyright. All rights reserved.