Adiposity, history of diabetes, and risk of pancreatic cancer in postmenopausal women
Menée aux Etats-Unis à partir de données portant sur 158 298 participantes, cette étude évalue l'association entre l'adiposité, mesurée par l'indice de masse corporelle, le tour de taille et le rapport taille/hanches, des antécédents de diabète et le risque de cancer du pancréas après la ménopause (durée médiane de suivi : 18 ans ; 1 054 cas)
Purpose : To examine the association of type 2 diabetes and anthropometric variables with risk of pancreatic cancer in a large cohort of postmenopausal women. Methods : Measured body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and self-reported history of diabetes were available for the entire cohort, and self-reported BMI earlier in life was available on about half of the cohort. After exclusions, 1,054 cases of pancreatic cancer were diagnosed among 158,298 women over a median of 18 years. Cox proportional hazards models were used to estimate the associations of study factors with risk of pancreatic cancer. Results : BMI, WC, and WHR showed modest positive associations with disease risk (HRs for highest vs. lowest level 1.20, 95% CI 0.96-1.51; 1.25, 95% CI 1.05-1.50; and 1.31, 95% CI 1.09-1.56, respectively). BMI earlier in life was not associated with disease. Diabetes showed a positive association with pancreatic cancer: HR 1.41, 95% CI 1.10-1.80. Conclusions : In this study of postmenopausal women, a history of diabetes was associated with increased risk of pancreatic cancer, and general and central adiposity were weak risk factors.