Dietary Heterocyclic Amine Intake and Colorectal Adenoma Risk: A Systematic Review and Meta-Analysis
A partir d'une revue systématique de la littérature (12 études), cette méta-analyse évalue l'association entre une exposition à des amines hétérocycliques d'origine alimentaire et le risque d'adénome colorectal
Background: Heterocyclic amines (HCAs) are potent carcinogenic substances formed in meat. Due to their mutagenic activity, they may increase the risk of colorectal adenomas (CRA), which are precursors of colorectal cancer (CRC), one of the most prevalent cancers worldwide. The aim of this meta-analysis was to synthesize the knowledge about the intake of HCAs and its associations with CRA.
Methods: We conducted a systematic search in PubMed and EMBASE. We used odds ratio (OR) (or relative risks, RR) from every reported intake and compared the highest versus lowest level of dietary HCAs. In addition, we assessed a dose-response relationship.
Results: Twelve studies on HCA intake and risk of CRA were included in our analysis. We observed a significant association when comparing top versus bottom intake category of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) (OR= 1.20, 95% CI=1.12 to 1.29), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) (OR=1.20; 95% CI=1.08 to 1.34), 2- amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) (OR=1.16; 95% CI=1.05 to 1.27), benzo(a)pyrene (BaP) (OR=1.15; 95% CI=1.04 to 1.27) and mutagenicity index (OR=1.22;95% CI=1.06 to 1.41). Furthermore, we observed a significant dose-response effect for PhIP, MeIQx and mutagenicity index.
Conclusion: This meta-analysis suggests that there is a positive association of HCAs, BaP, mutagenicity index with risk of CRA. Additionally, our dose-response analyses showed an increased risk for CRA in the case of PhIP, MeIQx and mutagenicity index.
Impact: This study provides evidence for a positive association between the dietary intake of meat mutagens and CRA risk.
Cancer Epidemiology Biomarkers & Prevention , résumé, 2017