Diet-Related Inflammation and Risk of Prostate Cancer in the California Men's Health Study
Menée aux Etats-Unis à partir de données portant sur 40 161 participants, cette étude évalue l'association entre une alimentation pro-inflammatoire et le risque de cancer de la prostate (durée de suivi : 9,7 ans ; 2 707 cas)
Purpose : Examine the relationship between pro-inflammatory diet and prostate cancer risk. Methods : Energy-adjusted Dietary Inflammatory Index (E-DII®) scores were computed among 40,161 participants in the California Men's Health Study. Over 9.7±3.8 years of follow-up 2,707 incident prostate cancer cases were diagnosed and categorized as low-, intermediate-, or high-risk, based on disease grade and stage. Accelerated failure-time models assessed time-to-diagnosis of prostate cancer. Cox proportional hazards models estimated hazard ratios (HR) and 95% confidence intervals (95% CI). Non-linear effects of E-DII were modeled as third-order polynomials. Results :Time-to-prostate-cancer-diagnosis did not differ by E-DII quartile. The HR for high-risk prostate cancer increased in the third E-DII quartile (HRQ3vsQ1=1.36; 95%CI:1.04-1.76), but not in the fourth (HRQ4vsQ1=0.99;95%CI:0.74-1.32, Ptrend=0.74) suggesting a non-linear dose-response. HR curves for prostate cancer increased exponentially above a threshold of ≈+3.0. HR curves for high-risk prostate cancer had a much steeper incline above an E-DII threshold of ≈+2.5. Curves were higher among Blacks and Whites relative to other races and among overweight or obese men. No relationship was observed between E-DII scores and intermediate- or low-risk disease. Conclusions : Relationships between pro-inflammatory diet and prostate cancer risk may be non-linear, with an increased risk above an E-DII threshold of ≈+2.5.