Metabolic Pathways in Kidney Cancer: Current Therapies and Future Directions
Ce dossier présente un ensemble d'articles concernant l'étiologie, l'épidémiologie, les biomarqueurs ou le traitement des cancers du rein
BackgroundRenal cell carcinoma (RCC) has become known as a metabolic disease, owing to the diverse array of metabolic defects and perturbations that occur as a result of the unique genetics that can drive these tumors. Recent attention to this feature of RCCs has fueled interest in targeting metabolism as a therapeutic strategy.MethodsWe conducted a literature search to develop themes around discrete pathways or processes of cellular metabolism, provide a framework for understanding emerging therapeutic strategies, and consider future interventions.ResultsDefects occur in metabolic pathways ranging from glycolysis to mitochondrial function and affect not only the tumor cell functionality, but also the local environment. We identified opportunities for therapeutic intervention associated with each pathway.ConclusionThe metabolism of RCC cells presents a special environment of tumor susceptibilities, with opportunities for novel imaging applications and treatment paradigms that are being tested in monotherapy or as adjuncts to targeted or immune-based strategies.
Journal of Clinical Oncology , article en libre accès, 2017