Aspirin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-Analysis
A partir d'une revue de la littérature et de données portant sur 4 533 patients atteints d'un gliome et sur 4 171 témoins entre 2010 et 2013, cette méta-analyse évalue l'association entre une utilisation d'aspirine et d'anti-inflammatoires non stéroïdiens et le risque de développer la maladie
Background: There have been few studies of sufficient size to address the relationship between glioma risk and the use of aspirin or non-steroidal anti-inflammatory drugs (NSAIDs), and results have been conflicting. The purpose of this study was to examine the associations between glioma and aspirin/NSAID use, and to aggregate these findings with prior published studies using meta-analysis. Methods: The Glioma International Case-Control Study (GICC) consists of 4,533 glioma cases and 4,171 controls recruited from 2010-2013. Interviews were conducted using a standardized questionnaire to obtain information on aspirin/NSAID use. We examined history of regular use for >=6 months and duration-response. Restricted maximum likelihood meta-regression models were used to aggregate site-specific estimates, and to combine GICC estimates with previously published studies. Results: A history of daily aspirin use for >=6 months was associated with a 38% lower glioma risk, compared to not having a history of daily use (adjusted meta-OR=0.62, 95% CI=0.54-0.70). There was a significant duration-response trend (p=1.67x10-17), with lower ORs for increasing duration of aspirin use. Duration-response trends were not observed for NSAID use. In the meta-analysis aggregating GICC data with five previous studies, there was a marginally significant association between use of aspirin and glioma (mOR=0.84, 95% CI=0.70-1.02), but no association for NSAID use. Conclusion: Our study suggests that aspirin may be associated with a reduced risk of glioma. Impact: These results imply that aspirin use may be associated with decreased glioma risk. Further research examining the association between aspirin use and glioma risk is warranted.