Does diabetes decrease the risk of glioma? A systematic review and meta-analysis of observational studies
A partir d'une revue systématique de la littérature publiée jusqu'en août 2018 (10 études), cette méta-analyse évalue l'association entre un diabète et le risque de gliome
Purpose : Increasing epidemiological evidence suggests that diabetes mellitus (DM) may be associated with a decreased risk of glioma. This systematic review assessed whether DM was associated with glioma risk. Methods : Electronic searches were performed in PubMed, Web of Science, Embase, and Cochrane Library databases up to August 30, 2018. A random-effects model was performed to calculate summary effect size with corresponding 95% confidence intervals (CIs). Results : In total, 10 studies (8 case-control studies and 2 cohort studies) matched the inclusion criteria. Meta-analyses of case-control studies showed that DM decreased the risk of glioma by 23% (odds ratio: 0.77, 95% CI, 0.61-0.96; P = 0.02, I2 = 82.0%). However, no such effect was observed in cohort studies (relative risk: 0.71, 95% CI, 0.10-4.80; P = 0.72, I2 = 61.6%). In the subgroup analyses, DM was associated with a decreased risk of glioma in Caucasians but not in Asians; the inverse association was slightly higher in males than in females. Conclusions : Our results indicate that DM decreases the risk of glioma, but the inverse association may vary in subgroups. The present conclusions should be confirmed with further studies.