Toward More Accurate Understanding of Lymph Node Metastasis Risk in Early Gastric CancerToward More Accurate Understanding of Lymph Node Metastasis Risk in Early Gastric CancerResearch
Menée en Chine à partir d'échantillons tumoraux prélevés sur 375 patients atteints d'un cancer gastrique de stade précoce et menée à l'aide de données clinico-pathologiques, cette étude multicentrique évalue la performance d'un modèle, basé sur les caractéristiques du collagène du micro-environnement tumoral, pour estimer le risque de métastases ganglionnaires
In this issue of JAMA Surgery, Chen et al add to an emerging understanding of biomarkers to determine individualized risk in gastric cancer. Early gastric cancer (EGC), in particular, requires precise risk stratification for more aggressive biology (ie, lymph node metastasis [LNM]). This concept is underscored by 3 findings: LNM has the strongest association with disease recurrence in resected EGC; nodal positivity is reproducibly associated with disease-specific death; and patients with T1a EGC are increasingly candidates for nonresectional interventions, such as endoscopic submucosal dissection, at expert centers.
Jama Surgery , commentaire, 2018