Childhood leukemia, late effects, and a person-centric model of follow-up
Menée au Danemark, en Suède, en Islande et en Finlande à partir de données portant sur 4 003 patients ayant survécu 5 ans ou plus à une leucémie pédiatrique diagnostiquée entre 1970 et 2008 et sur 129 828 témoins, cette étude analyse le taux d'hospitalisation à long terme en lien avec 120 types de maladies
Survival after childhood cancer has substantially improved over the last half century with the introduction of chemotherapy. This is particularly true for leukemia, the most common form of childhood cancer, as it was considered incurable in the 1960s, but with combination chemotherapy the 5-year survival rates rose to 50% in 1975-1977 and ultimately 88% in 2007-2013 in the United States.
With time it has become clear that these life-saving therapies may also have a long-term impact on the childhood cancer survivor, with physical and psychosocial long-term and late effects appearing not only during or soon following treatment, but also decades later. Thus, there is a need to understand the long-term consequences of cancer therapy in order to risk stratify patients for upfront therapy and to monitor post therapy, following the paradigm described by Meadows to ‘maximize cure, minimize cost’. (...)
Journal of the National Cancer Institute , éditorial, 2018