Association of Indoor Tanning Exposure with Age at Melanoma Diagnosis and BRAF V600E Mutations
Menée à partir de données portant sur 114 patients américains, cette étude analyse l'association entre l'utilisation de cabines de bronzage et le risque de mélanome, en prenant en compte l'âge et la présence d'une mutation V600E sur le gène BRAF
There is limited information on how indoor tanning (IT) promotes melanoma development. We investigated IT use in patients with melanomas in sun-exposed skin and studied the clinicopathological and molecular characteristics in relation to IT exposure. We accrued patients from December 2013 to May 2015. The 114 patients who reported IT exposure were younger at diagnosis than the 222 patients who did not (51.5 vs 64.0 years, P < .001). BRAF V600E genotype was more prevalent in ever-users than in non-users (42.9% vs 28.3% respectively, P = .04) and higher in ever-users who initiated IT prior to age 25 years compared to age 25 or older (62.2% vs 31.1%, P = .003). There were more melanomas in intermittently sun-exposed skin in ever-users than non-users (65.7% vs 51.9% respectively, P = .02). Our data suggest IT may promote melanomas that arise in skin with low-chronic sun-induced damage through BRAF V600E-mediated melanomagenesis.