Circulating Inflammation Proteins Associated with Lung Cancer in African Americans
Menée aux Etats-Unis à partir d'échantillons sanguins prélevés sur 705 patients atteints d'un cancer du poumon et 909 témoins, cette étude identifie 10 protéines inflammatoires associées au cancer du poumon et spécifiques à la population afro-américaine
Introduction : Lung cancer incidence is higher among AAs compared with European Americans in the United States. We, and others, previously demonstrated a relationship between immune and inflammation proteins with lung cancer in European Americans. Our aim was to investigate the etiological relationship between inflammation and lung cancer in African Americans. Methods : We adopted a two stage, independent study design (discovery n=316 cases and n=528 controls) (validation n=399 cases and 400 controls) and measured 30 inflammation proteins in blood using Mesoscale V-Plex multiplex assays. Results : We identified, and validated, ten proteins associated with lung cancer in AAs, some that were common between EA and AA (CRP (OR, 2.90; 95% CI, 1.99-4.22), IFN-
γ (OR, 1.55; 95% CI, 1.10-2.19), IL-6 (OR, 6.28; 95% CI, 4.10-9.63), IL-8 (OR, 2.76; 95% CI, 1.92-3.98) and some that are only observed among AA (IL-10 (OR, 1.69; 95% CI, 1.20-2.38), IL-15 (OR, 2.83; 95% CI, 1.96-4.07), IP-10 (OR, 1.54; 95% CI, 1.09-2.18), MCP-4 (OR, 0.54; 95% CI, 0.38-0.76), MIP-1 α (OR, 1.57; 95% CI, 1.12-2.21), and TNF- β (OR, 0.52; 95% CI, 0.37-0.74). We did not find evidence that either menthol cigarette smoking or global genetic ancestry drove these population differences. Conclusions
:
Our results highlight a distinct inflammation profile associated with lung cancer in AAs compared with EAs. These data provide new insight into the etiology of lung cancer in AAs. Further work is needed to understand what drives this relationship with lung cancer and whether these proteins have utility in the setting of early diagnosis.