• Etiologie

  • Facteurs exogènes : Nutrition et activité physique

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A prospective study of dairy product intake and the risk of hepatocellular carcinoma in U.S. men and women

Menée aux Etats-Unis à partir de données portant sur 51 418 hommes et sur 93 427 femmes, cette étude de cohorte prospective analyse l'association entre une consommation de produits laitiers et le risque de carcinome hépatocellulaire (durée de suivi : 32 ans ; 164 cas)

Although increasing dairy product intake has been associated with risk of several cancers, epidemiological studies on hepatocellular carcinoma are sparse and have yielded inconsistent results. We prospectively assessed the associations of dairy products (total, milk, butter, cheese, and yogurt) and their major components (calcium, vitamin D, fats, and protein) with the risk of hepatocellular carcinoma development among 51,418 men and 93,427 women in the Health Professionals Follow-up Study and the Nurses' Health Study. Diets were collected at baseline and updated every 2-4 years using validated food frequency questionnaires. Multivariable hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated using Cox proportional hazards regression model. During up to 32 years of follow-up, a total of 164 hepatocellular carcinoma cases were documented. After adjustment for most known hepatocellular carcinoma risk factors, higher total dairy product intake was associated with an increased risk of hepatocellular carcinoma (highest vs. lowest tertile, HR=1.85, 95%CI: 1.19-2.88; Ptrend=0.009). For the same comparison, we observed significant positive associations of high-fat dairy (HR=1.81, 95%CI: 1.19-2.76; Ptrend=0.008) and butter (HR=1.58, 95%CI: 1.06-2.36; Ptrend=0.04) with hepatocellular carcinoma risk. There was a non-significant inverse association between yogurt intake and hepatocellular carcinoma risk (HR=0.72, 95%CI: 0.49-1.05; Ptrend=0.26). Our data suggest that higher intake of high fat dairy foods was associated with higher, whereas higher yogurt consumption might be associated with lower risk of developing hepatocellular carcinoma among U.S. men and women. This article is protected by copyright. All rights reserved.

International Journal of Cancer

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