Global Increasing Incidence of Young-Onset Colorectal Cancer Across 5 Continents: A Joinpoint Regression Analysis of 1,922,167 Cases
Cette étude analyse, au niveau mondial sur la période 1988-2007, l'évolution de l'incidence du cancer colorectal chez les personnes âgées de moins de 50 ans
Background: Colorectal cancer (CRC) incidence among young adults in the United States (US) is on the rise, but whether this phenomenon is present in other parts of the world is not well documented. This study aims to explore the temporal change of incidence rates for CRC in various countries across the globe. Methods: We extracted CRC incidence and population data from 1988-2007 based on data from the International Agency for Research on Cancer and compared incidence between age groups. Twelve representative jurisdictions from five continents were selected. Young-onset CRC cases were defined as those aged < 50 years. Joinpoint regression was used to measure the trends of CRC incidence, and to estimate the annual percent change (APC). Results: The APC for those aged <50 years was noted to be increasing at a faster rate as compared with those aged >50 in many regions including: Australia (+1.10% vs -0.35%), Brazil (+9.20% vs +5.72%), Canada (+2.60% vs -0.91%), China - Hong Kong (+1.82% vs -0.10%), China - Shanghai (+1.13% vs -2.68%), Japan (+2.63% vs +0.90%), the United Kingdom (+3.33% vs +0.77%) and the United States (+1.98% vs -2.88%). These trends were largely driven by rectal cancer, except in Brazil and the United Kingdom. Conclusions: Increasing incidence of young-onset CRC was noted in many regions across the globe. Further studies focusing on young-onset colorectal cancer, particular with regard to risk factors and establishing the optimal age of screening is warranted.