Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome
A partir de données portant au total sur 9 087 témoins et 2 299 personnes atteintes de leucémie aiguë lymphoblastique, cette étude d'association sur le génome entier identifie, chez les enfants présentant ou non une trisomie 21, un locus de susceptibilité à la maladie sur le chromosome 21
Children of Latino ancestry have ~1.6-fold increased risk of acute lymphoblastic leukemia (ALL) relative to non-Latino white children, partly explained by the higher frequency of common heritable ALL risk alleles at ARID5B, GATA3, and PIP4K2A in Latinos. However, the etiologies of the increased ALL risk in Latinos have not been fully elucidated. We previously performed a large, multi-ethnic genome-wide association study (GWAS) of childhood ALL, including 3,263 cases of which ~60% were of Latino ethnicity. While we identified two novel risk loci, we did not identify Latino-specific risk loci, unlike a recent report from Qian et al.. We have performed whole-genome imputation of our Latino dataset and combined it with GWAS data from two additional, non-overlapping Latino childhood ALL case-control datasets to identify novel and/or Latino-specific risk loci.