Association of BMI, smoking and alcohol with multiple myeloma mortality in Asians: a pooled analysis of more than 800,000 participants in the Asia Cohort Consortium
Menée à partir de données portant sur 805 309 patients asiatiques atteints d'un myélome multiple, cette étude analyse l'association entre l'indice de masse corporelle, une pratique tabagique, une consommation d'alcool et la mortalité spécifique (période de suivi :10 221 623 personnes-années)
Background : To date, few epidemiological studies have been conducted to elucidate lifestyle-related risk factors for multiple myeloma (MM) in Asia. We investigated the association of body mass index (BMI), smoking, and alcohol intake with the risk of MM mortality through a pooled analysis of more than 800,000 participants in the Asia Cohort Consortium.
Methods : The analysis included 805,309 participants contributing 10,221,623 person-years of accumulated follow-up across Asia Cohort Consortium cohorts. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the association between BMI, smoking and alcohol at baseline and the risk of MM mortality were assessed using a Cox proportional hazards model with shared frailty.
Results : We observed a statistically significant dose-dependent association between BMI categories and the risk of MM mortality (<18.5 kg/m2: HR=0.80, 95% CI: 0.52-1.24; 18.5 to 24.9 kg/m2: reference; 25.0 to 29.9 kg/m2: HR=1.17, 0.94-1.47; ≥30 kg/m2: HR=1.61, 0.99-2.64, p for trend=0.014). By sex, this association was more apparent in women than in men (P for heterogeneity between sexes=0.150). We observed no significant associations between smoking or alcohol consumption and risk of MM mortality.
Conclusion : This study showed that excess body mass is associated with an increased risk of MM mortality among Asian populations. In contrast, our results do not support an association between smoking or alcohol consumption and the risk of MM mortality in Asian populations.
Impact : This study provides important evidence on the association of BMI, smoking and alcohol with the risk of MM mortality in Asian populations.
Cancer Epidemiology Biomarkers & Prevention , résumé, 2018