Antihypertensive drugs and pancreatic cancer risk in patients with chronic pancreatitis: a Danish nationwide population-based cohort study
Menée au Danemark à partir de données portant sur 8 311 patients atteints d'une pancréatite chronique diagnostiquée entre 1996 et 2012, cette étude de cohorte analyse l'association entre une utilisation de médicaments anti-hypertenseurs et le risque de cancer du pancréas (153 cas)
Background : Antihypertensives may inhibit pancreatic carcinogenesis. We examined the association between use of these drugs and pancreatic cancer in patients with chronic pancreatitis. Methods : We conducted a nationwide population-based cohort study of all chronic pancreatitis patients diagnosed in Denmark during 1996–2012. Using a Cox proportional hazards model with time-varying exposure lagged by 1 year, we examined the risk of pancreatic cancer according to antihypertensive drug use. Results : We included 8,311 patients with chronic pancreatitis and observed 153 pancreatic cancers during follow-up. At baseline, 2197 patients (26.4%) were exposed to at least one class of antihypertensive drugs. We did not observe any measurable associations between the use of antihypertensive drugs and pancreatic cancer. Conclusions : Our findings suggest little evidence of an association between the use of antihypertensive drugs and pancreatic cancer risk in patients with chronic pancreatitis. Confirmation is warranted in future studies.