Processed meat intake and bladder cancer risk in the prostate, lung, colorectal and ovarian (PLCO) cohort
Menée aux Etats-Unis auprès de 101 721 participants de l'essai "Prostate, Lung Colorectal and Ovarian Cancer Screening Trial" (durée médiane de suivi : 12,5 ans), cette étude analyse l'association entre une consommation de viande transformée et le risque de cancer de la vessie (776 cas)
Background : The association between processed meat intake and bladder cancer risk has been evaluated by several observational studies with inconsistent results. Methods : In a cohort of 101,721 subjects in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, we analyzed the association of processed meat intake with bladder cancer risk. Results : After a median of 12.5 years of follow-up, 776 new cases of bladder cancer were identified. Intake of processed red meat was significantly associated with the incidence of bladder cancer after multivariate adjustment (Highest vs. lowest quintile: HR 1.47, 95% CI 1.12-1.93; P for trend = 0.008). By contrast, there was only a suggestive but not significant association between intake of total processed meat and bladder cancer risk after multivariable adjustment (Highest vs. lowest quintile: HR 1.16, 95% CI: 0.89-1.50; P for trend = 0.073). Conclusion : This large prospective study suggests that intake of processed red meat is associated with a higher risk of bladder cancer. Impact : Bladder cancer risk is increased with cumulative intake of processed red meat.