Excess Body Weight and the Risk of Liver Cancer: Systematic Review and a Meta-Analysis of Cohort Studies
A partir d'une revue systématique de la littérature publiée jusqu'en septembre 2018 (37 études), cette méta-analyse évalue l'association entre l'indice de masse corporelle et le risque de cancer du foie
Objective : To update and expand the previous meta-analysis including all prospective studies on the issue of the associations between overweight, obesity, and liver cancer risk. We also performed a meta-regression to investigate a potential nonlinear and/or linear association between body mass index (BMI) and liver cancer risk. Methods : Literature search was conducted in four libraries from the beginning of indexing for each database to 1st September, 2018. Results : The summary risk estimate was statistically significant on the association between overweight and the risk of liver cancer incidence (relative ratio [RR]?=?1.19). The RRs were significantly stronger in people with known liver disease with overweight than in the general population with overweight (RR?=?1.50 vs. RR?=?1.10; Pdifference?=?.02). The meta-analysis showed an increase by 87% on the risk of liver cancer incidence in obesity categories, relative to categories of normal BMI (RR?=?1.87, P?<?.01). Moreover, the results showed that, overweight was associated with 9% increased and obesity with 66% increased for risk of liver cancer mortality. In linear model, the relative risks of liver cancer were 1.32 for continuous BMI per 5?kg/m2 increase. Conclusion : This meta-analysis supports the hypothesis that overweight, obesity may significantly increase liver cancer risk.