Emerging Use of CRISPR Technology — Chasing the Elusive HIV Cure
Menée sur un patient infecté par le VIH-1 et atteint d'une leucémie lymphoblastique aiguë, cette étude analyse l'efficacité et les événements indésirables d'une stratégie thérapeutique consistant à effectuer une greffe de cellules progénitrices et de cellules souches hématopoïétiques dont le récepteur CCR5 a été supprimé à l'aide de la technologie CRISPR
A new form of gene therapy termed genetic editing or gene targeting has become possible owing to advances in genetic engineering technology.1 The intent of genetic editing is to alter the DNA code in cells with single base-pair specificity, and thus it can be considered to be an ultimate form of precision therapy. For the past two decades, genome editing has been a powerful tool for basic science research. The importance of genome editing as a research tool was recognized in 2007 by the award of the Nobel Prize in Physiology or Medicine to Smithies, Capecchi, and Evans. Until recently, . . .
New England Journal of Medicine , éditorial, 2019