Impact of fear of cancer recurrence on survival among lymphoma patients
Mené en Corée à partir de données portant sur 467 patients ayant survécu à un lymphome, cette étude de cohorte prospective analyse l'association entre la sévérité de leur peur de la récidive et leur qualité de vie (état de santé physique, psychique et relations sociales) ainsi que la mortalité spécifique et toutes causes confondues
Objective : This study aimed to evaluate FCR among lymphoma patients who completed treatment and its impact on survival and quality of life (QOL). Methods : In this prospective cohort study, 467 lymphoma patients were included who completed treatment with curative intent between Feb 2012 and March 2017. FCR was measured using a question from the Korean version of the QOL in Cancer Survivors Questionnaire. QOL and general health and functioning were measured using the EORTC QLQ‐C30. Participants were actively followed up for all‐cause and disease‐specific mortality. Results : In total, 16.3% of the patients had severe FCR. The adjusted Hazard Ratio (HR) for all‐cause mortality comparing participants with and without severe FCR was 2.52 (95% CI = 1.15, 5.54), and the association was stronger in indolent non‐Hodgkin's lymphoma (NHL) (HR = 6.77; 95% CI = 1.04, 43.92). Participants with severe FCR were also at higher risk of lymphoma‐specific mortality (HR = 2.62; 95% CI = 1.13, 6.05) than patients without severe FCR. Patients with severe FCR had significantly worse general health status (64.3 vs. 71.0, p = 0.03) and physical (82.4 vs. 76.7, p <0.01), emotional (68.5 vs. 84.8, p <0.001), and social functioning (67.8 vs. 84.2, p <0.001) than patients without severe FCR. Conclusions : A substantial number of participants with lymphoma experience FCR after treatment completion, even in the case of indolent lymphomas. Given the negative impact of severe FCR on survival and general health and functional status, active monitoring and appropriate management of FCR should be considered in clinical settings.
Psycho-Oncology 2019