Relationship between meat/fish consumption and biliary tract cancer: The Japan Public Health Center-based Prospective Study
Menée au Japon sur la période 1995-1999 auprès de 98 663 personnes (âge : 45-74 ans ; durée de suivi : 5 ans), cette étude analyse l'association entre une consommation de viande et de poisson et le risque de cancer des voies biliaires (379 cas)
Background : The effect of meat and fish consumption on cancer risk has been well studied in humans. However, studies related to biliary tract cancer (BTC) are scarce. Methods : We examined the association between meat and fish consumption and the risk of BTC in a population-based prospective cohort study in Japan. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using the Cox proportional hazard model. Results : During 1995-1999, 43,177 men and 49,323 women aged 45-74 years were enrolled and followed up for 607,757.0 person-years (men) and 728,820.3 person-years (women) until 2012, during which time 217 male and 162 female BTC cases were identified. Higher total meat consumption was significantly associated with a decreased BTC risk in men (HR for the highest versus lowest quartiles = 0.66; 95% CI: 0.44-0.98; P-trend = 0.011) but not in women. Similar association was observed with red meat, but no association was observed with poultry. Fish was not associated with BTC risk. We further analyzed each BTC subtype to confirm the observed association with BTC. However, significant association with each of BTC subtype was not observed, although a trend of decreased extrahepatic BDC risk was observed. Conclusions : BTC risk was lower among men who consumed more meat, particularly red meat, in Japan. Impact : This is the first prospective study that evaluated the relationship between meat and BTC. This may provide important suggestions to elucidate the etiology of BTC.