Vitamin D Binding Protein and Risk of Renal Cell Carcinoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO)
Couplée aux données de l'essai "Prostate, Lung, Colorectal, and Ovarian Cancer Screening" et portant sur 323 patients atteints d'un carcinome à cellules rénales et sur 323 témoins, cette étude analyse l'association entre le niveau sérique de protéine de liaison à la vitamine D et le risque de développer la maladie
Our group has conducted two previous studies on the association between vitamin D binding protein (DBP) and renal cell carcinoma (RCC), the most common form of kidney cancer, finding strong inverse associations. We undertook the current analysis to replicate our findings in a different study population that included women and non-smokers. We conducted a nested case‐control study in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO). Cases (n=323) were matched 1:1 to controls on age (+/‐ 1 year), race, date of blood collection (+/‐ 30 days) and sex. We performed conditional logistic regression to estimate the odds ratios and 95% confidence intervals for the association between quartiles of circulating DBP and risk of RCC. We observed a statistically significant positive association between DBP and RCC that persisted after adjustment for history of diabetes, history of hypertension, family history of renal cancer, body mass index (BMI), and smoking status (mv‐adj Q4 vs. Q1 OR=4.1, 95% CI=2.2‐7.8; p‐trend <0.0001). These findings were similar when we restricted to cases with at least two years of follow‐up and no major weight loss, suggesting that our findings are not due to reverse causality. In the present study, those with higher serum concentrations of DBP were at increased risk of RCC, in contrast to previously published findings. Further research is necessary to determine the true association between DBP and risk of RCC, and whether different DBP phenotypes may have different associations with risk of RCC.