Microenvironmental heterogeneity among triple negative breast cancer subtypes and the promise of precision medicine
A partir de l'analyse de 1 512 échantillons tumoraux issus de différents sous-types moléculaires de cancer du sein triplement négatif, cette étude met en évidence un microenvironnement tumoral distinct pour chacun de ces sous-types moléculaires
Theadvent of molecular tumor characterizationhas clearly identifiedthat breast cancer is not a single diseaseentity, but rather a class ofseveraldistinct subtypes, each with its own natural history and therapeutic susceptibilities. The field initially focused on characterizing tumors by using gene expression profiling to identify those that were estrogen receptor positive (ER+) or negative (ER-),1with subsequent microarray analyses revealing4-5 major subtypes that are now viewed as canonical determinants of prognosis, treatmentselection,and risk stratification.2-4 In this framework, triple negative breast cancers (TNBC) became the most therapeutically challenging and prognostically adverse group, as they did not have a clear oncogenictarget:neither ER/PR for endocrine modulation nor HER2/neu amplification for HER2-directed therapy.
Journal of the National Cancer Institute , éditorial en libre accès, 2018